Original article
Published: 2026-03-09

The impact of two-stage newborn hearing screening protocol for early diagnosis of hearing loss

Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples
https://orcid.org/0000-0003-2728-339X
Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples
Audiology and Vestibology Unit, Federico II University Hospital, Naples
https://orcid.org/0000-0003-0614-7583
Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples
Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples
Department of Pediatrics, Santobono Pausilipon Hospital, Naples
Department of Maternal and Child Health, General Directorate for Health, Naples
Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples
https://orcid.org/0000-0001-5405-4301
Universal Newborn hearing screening; permanent hearing loss; discordant outcomes; mild hearing loss;

Abstract

Objective: Early detection and prompt intervention of Permanent Hearing Impairment (PHI) can only be achieved through Universal Newborn Hearing Screening (UNHS) in the first month of life. The most common screening worldwide protocols involve the combined approach with transient evoked otoacoustic emissions (TEOAEs) and automated auditory brainstem response (AABR). Our study aims to evaluate the rate of infants with PHI in a population with discordant outcome TEOAEs/AABR through an audiological follow up. Methods:  The present study enrolled 637 well babies who failed TEOAEs at birth and were referred for a secondary level audiological evaluation with TEOAEs and AABR. Ninety babies with discordant outcome (TEOAEs refer/AABR pass) underwent to audiological retest adding tympanometry and clinical click-evoked auditory brainstem response. Results: The PHI was confirmed in 12 babies (7 bilaterally and 5 unilaterally) and the degree was by mild to moderate in 8 and in 4 babies, respectively. There was not risk factors for delayed onset of hearing loss in half of PHI. Conclusion: The discordance TEOAEs refer/AABR pass suggests that a follow-up should be recommended independently of the risk factors for PHI to avoid misleading diagnosis of mild or late-onset hearing loss.

Affiliations

Rita Malesci

Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples

Chiara Quatrano

Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples

Valeria Del Vecchio

Audiology and Vestibology Unit, Federico II University Hospital, Naples

Giovanni Freda

Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples

Antonella Castaldi

Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples

Francesco Nunziata

Department of Pediatrics, Santobono Pausilipon Hospital, Naples

Pietro Buono

Department of Maternal and Child Health, General Directorate for Health, Naples

Anna Rita Fetoni

Audiology Section, Department of Neuroscience and Reproductive Sciences and Dentistry, University of Naples Federico II, Naples

Copyright

© Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale , 2026

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