Bama pig is a suitable animal for studying laryngopharyngeal reflux disease| ACTA Otorhinolaryngologica Italica

Abstract

Objective: To evaluate whether Bama pig is suitable for studying LPRD.

Methods: Sixteen 8-month male Bama pigs were measured how far UES and LES were away from incisor tooth and their contraction intensity by esophageal manometry. Sixteen Bama pigs were randomly divided into three groups (n=6, 5, 5). For the first group, 24h fasting and 6h water deprivation was required and monitoring process was conducted under anesthesia. The second group was anesthetized 2h after normal feeding and then underwent pH monitoring. The third was also anesthetized 2h after eating but monitored awake.

Results: The distance of UES away from incisor is 19.8±1.0cm and of LES is 40.0[39.5, 42]cm. Abd the Bama pig’s resting pressure of UES is 64±12mmHg and of LES is 20±4mmHg. Laryngopharyngeal pH values of three groups are 6.9±0.4, 7.2±0.3 and 7.2±0.6 respectively and show no significant difference and reflux events. The pH of lower esophagus of the first group Bama pigs is 6.1±0.8 and of the second is 6.9±0.4, with no significance difference as well.

Conclusion: Bama pig is an ideal animal for studying LPRD. It’s convictive to establish a Bama pig reflux model and study mechanisms of LPRD.